PEGylation Technology

PEGylation is the chemical linkage of polyethylene glycol polymer chains to various APIs, primarily to increase in vivo half-life and stability of the product. BioTechLogic has experience managing pre-qualification and optimization studies for PEGylation reactions. Our experience includes the development and validation of the following reaction parameters:

  • Molar ratio of PEG reagent to product
  • Time
  • Temperature
  • Mixing and static reactions
  • Reagent stability
  • In-process hold times